Xiao-Cui Yuan,1 Qiang Wang,2 Wen Decor Su,3 Hong-Ping Li,1 Cai-Hua Wu,3 Fang Gao,1 Hong-Chun Xiang,1 He Zhu,1 Li-Xue Lin,1 Xue-Fei Hu,1 Jie Cao,4 Jing-Jing Li,1 Man Li1 1Department of Neurobiology and Key Laboratory of Neurological Diseases of Ministry of Education, The Institute of Brain Research, School of Basic Medicine, Tongji Medical College o
Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis
Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant t
Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma
Background: Sinonasal inverted papilloma (IP) is a rare benign tumor of the nasal cavities and paranasal sinuses.It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential.The present study aimed to perform a retrospective analysis Floor Runners of patients with squamous cell carcinoma (
Extensive Bone Marrow Necrosis in a Case of Acute Myeloid Leukemia Transformed from a Myeloproliferative Neoplasm
Extensive necrosis affecting more than 50% of the bone marrow is an extremely rare histopathological finding.Relatively little is known about its clinical significance because it is Decor most commonly identified at autopsy - whether it is an independent prognostic marker or whether it is a surrogate marker of underlying disease burden remains uncl
Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress
Dishwasher Drain Hose Holder Hyperglycemia induces chronic inflammation and oxidative stress in cardiomyocyte, which are the main pathological changes of diabetic cardiomyopathy (DCM).Treatment aimed at these processes may be beneficial in DCM.Phloretin (PHL), a promising natural product, has many pharmacological activities, such as anti-inflammato